Xu X, P Chen , J Wang , J Feng , H Zhou , X Li , W Zhong and P Hao. Briefly, after removal of blood vessels, the mesenchymal tissue was cut into small fragments and centrifuged at 250 g for 5 min at room temperature. Global mortality is reported to be 4.7% but varies widely by location between a reported low of 0.7% in Germany and a high of 10.8% in Italy [6]. We therefore conducted a clinical trial pilot study [14]. The cell product has been certified by the National Institutes for Food and Drug Control of China (authorization number: 2004L04792, 2006L01037, CXSB1900004). This paper is a review focused on the discovery of different stem cells and the potential therapies based on these cells. 33, No.

Zhao RC(1). For a long time at the end of each year, I’ve been making stem cell predictions for the coming year. 3. However, we have neither confirmed effective antiviral medications nor vaccines available to deal with this emergency. You can see how I did for 2018 here, which might have been my best year ever for predictions. Based on those results, we believe that ACE2– MSCs could be beneficial for patients with COVID-19. Umbilical cords were obtained from two healthy donors after normal deliveries of 38- to 40-week gestation with informed consent. Copyright 2020, Mary Ann Liebert, Inc., publishers, 11 August 2020 | Human Cell, Vol. The novel coronavirus disease 2019 (COVID-19) has grown to be a global public-health emergency since patients were first detected in Wuhan, China, in December 2019. COVID‐19 Thus, the intravenous transplantation of MSCs was safe and effective for treatment in patients with COVID-19 pneumonia, especially for patients whose condition was critically severe. 4, 29 September 2020 | Human Vaccines & Immunotherapeutics, Vol.

The resultant pellets were washed with serum-free Dulbecco's modified Eagle's medium (DMEM). The genesis of stem cells is followed by laboratory steps of controlled stem cell culturing and derivation. 50, No. In that June 2019 decision, U.S. district Judge Ursula Ungaro of Miami ordered U.S. 21, European Journal of Pharmacology, Vol. We also reported that MSCs could decrease the differentiation of classical DCs from human CD34+ cells while increasing the differentiation of regDC, published in the Journal of Immunology [12,13]. Department of Cell Biology, School of Life Sciences, Shanghai University, Shanghai, PR China. © 2020 Mary Ann Liebert, Inc., publishers. Meanwhile, the level of TNF-α decreased significantly, and IL-10 increased in the MSC treatment group compared to the placebo control group. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission, Hoffmann M, H Kleine-Weber , S Schroeder , N Krüger , T Herrler , S Erichsen , TS Schiergens , G Herrler , N-H Wu , A Nitsche , MA Müller , C Drosten and S Pöhlmann, SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Lu R, X Zhao , J Li , P Niu , B Yang , H Wu , W Wang , H Song , B Huang , N Zhu , Y Bi , X Ma , F Zhan , L Wang , T Hu , H Zhou , Z Hu , W Zhou , L Zhao , J Chen , Y Meng , J Wang , Y Lin , J Yuan , Z Xie , J Ma , WJ Liu , D Wang , W Xu , EC Holmes , GF Gao , G Wu , W Chen , W Shi and W Tan, Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding, Guo H, Hu Y, Liao LM, Jiang XY, Liu JW, Ma L, Ma GJ, Zhao ZG, Yang SG, and RC Zhao, Postembryonic subtotipotent stem cells derived from a variety of fetal tissues have multiple differentiation potential and greatly contribute to stem cell plasticity, Zhang B, R Liu , D Shi , X Liu , Y Chen , X Dou , X Zhu , C Lu , W Liang , L Liao , M Zenke and RC Zhao, Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2–dependent regulatory dendritic cell population, Liu X, X Qu , Y Chen , L Liao , K Cheng , C Shao , M Zenke , A Keating and RC Zhao, Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation, Liu X, S Ren , C Ge , K Cheng , M Zenke , A Keating and RC Zhao, Sca-1(+)Lin(–)CD117(–) mesenchymal stem/stromal cells induce the generation of novel IRF8-controlled regulatory dendritic cells through Notch-RBP-J signaling, Leng Z, R Zhu , W Hou , Y Feng , Y Yang , Q Han , G Shan , F Meng , D Du , S Wang , J Fan , W Wang , L Deng , H Shi , H Li , Z Hu , F Zhang , J Gao , H Liu , X Li , Y Zhao , K Yin , X He , Z Gao , Y Wang , B Yang , R Jin , I Stambler , LW Lim , H Su , A Moskalev , A Cano , S Chakrabarti , KJ Min , G Ellison-Hughes , C Caruso , K Jin and RC Zhao, Transplantation of ACE2- mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia, Leng Z, D Yin , Z Zhao , M Yan , Y Yang , X He , RC Zhao and H Liu, A survey of 434 clinical trials about coronavirus disease 2019 in China, Mesenchymal stem cells and exosome therapy for COVID-19: current status and future perspective, BCG vaccine: a hope to control COVID-19 pandemic amid crisis, Mesenchymal Stromal Cells in Viral Infections: Implications for COVID-19.

88, No. Next, the cells were treated with 2 mg/mL collagenase type I solution for 4 h at 37°C, washed, and treated with 0.25% trypsin for 30 min at 37°C with agitation. Stem cells have been widely studied in the fields of cancer biology. But in China, the stem cell clinical trials are under the strict supervision of the National Health Commission of China or the National Institutes for Food and Drug Control of China. Deciphering SARS-CoV-2 Virologic and Immunologic Features, Mesenchymal Stem Cells in COVID-19: A Journey from Bench to Bedside, The rationale of using mesenchymal stem cells in patients with

Yet, many fundamental questions regarding the specific roles of stem cell in cancer progression and therapy remain elusive, impeding the effective clinical translation of stem cell research. Furthermore, interleukin-10 (IL-10) plays an essential role in maintaining the immunomodulatory property of regDC. 1, 2 June 2020 | Innovative medicine of Kuban, No. All these interactions with different dendritic cells lead to a shift of the immune system from Th1 toward Th2 responses. Surface markers of UC-MSCs detected by flow cytometric should be positive (>95%) for CD90, CD105, and CD73 and negative for CD45, CD34, CD31, and HLA-DR. Quality control for the MSC included identity, purity, and safety, and differentiation potency evaluations were conducted following culture of the MSCs. 8, 30 June 2020 | Ukrainian Journal of Modern Toxicological Aspects, Vol. 16, 30 July 2020 | Laboratory Medicine, Vol. In this commentary, we offer an alternative promising therapy for COVID-19, that is, mesenchymal stem cell transplantation. ‐related acute respiratory distress syndrome: What to expect, The Coronavirus Pandemic (SARS-CoV-2): New Problems Demand New Solutions, the Alternative of Mesenchymal (Stem) Stromal Cells, Toxicologist`s opinion on the mechanisms of virus-induced hemoglobinopathies with toxic pneumonitis and systemic hypoxemia from COVID-19 and substantiation of rational detoxification methods, PATHOGENETIC RATIONALE FOR THE USE OF СELL THERAPY IN LUNG INJURY ASSOCIATED WITH SARS-COV-2, PCR detection and new therapies for COVID-19. 21, No. However, we have neither confirmed effective antiviral medications nor vaccines available to deal with this emergency. UC-MSCs were isolated and cultured under Good Manufacturing Practice (GMP) conditions. The novel coronavirus disease 2019 (COVID-19) has grown to be a global public-health emergency since patients were first detected in Wuhan, China, in December 2019. 382, 16 July 2020 | Frontiers in Cell and Developmental Biology, Vol. Huang C, Y Wang , X Li , L Ren , J Zhao , Y Hu , L Zhang , G Fan , J Xu , X Gu , Z Cheng , T Yu , J Xia , Y Wei , W Wu , X Xie , W Yin , H Li , M Liu , Y Xiao , H Gao , L Guo , J Xie , G Wang , R Jiang , Z Gao , Q Jin , J Wang and B Cao, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Guan WJ, ZY Ni , Y Hu , WH Liang , CQ Ou , JX He , L Liu , H Shan , CL Lei , DSC Hui , B Du , LJ Li , G Zeng , KY Yuen , RC Chen , CL Tang , T Wang , PY Chen , J Xiang , SY Li , JL Wang , ZJ Liang , YX Peng , L Wei , Y Liu , YH Hu , P Peng , JM Wang , JY Liu , Z Chen , G Li , ZJ Zheng , SQ Qiu , J Luo , CJ Ye , SY Zhu and NS Zhong, Clinical characteristics of coronavirus disease 2019 in China, Grasselli G, A Zangrillo , A Zanella , M Antonelli , L Cabrini , A Castelli , D Cereda , A Coluccello , G Foti , R Fumagalli , G Iotti , N Latronico , L Lorini , S Merler , G Natalini , A Piatti , MV Ranieri , AM Scandroglio , E Storti , M Cecconi , A Pesenti and COVID-19 Lombardy ICU Network, Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy, Young BE, SWX Ong , S Kalimuddin , JG Low , SY Tan , J Loh , O-T Ng , K Marimuthu , LW Ang , TM Mak , SK Lau , DE Anderson , KS Chan , TY Tan , TY Ng , L Cui , Z Said , L Kurupatham , MI-C Chen , M Chan , S Vasoo , L-F Wang , BH Tan , RTP Lin , VJM Lee , Y-S Leo , DC Lye and Singapore 2019 Novel Coronavirus Outbreak Research Team, Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore, Diagnosis and treatment protocol for novel coronavirus pneumonia (trial version 7), The COVID-19 pandemic in the US: a clinical update. The novel coronavirus disease 2019 (COVID-19) has grown to be a global public-health emergency since patients were first detected in Wuhan, China, in December 2019.

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